Nucleophilic-Substitution-1

Nucleophilic Substitution Reaction

Mechanism of bimolecular (S_N2) nucleophilic substitution [Mechanism & Kinetics]

An S_N2 reaction proceeds with complete stereo chemical inversion.

S_N2 reaction decreases with stearic hinderance and increases by presence of nonprotic solvent for example DMF and DMSO. S_N2 reaction decreases in the presence of protic solvent like CH₃OH, C₂H₅OH, HF etc.

As the size of alkyl group increases than chemical reactivity towards S_N2 decreases.

As the size of alkyl group increases sterichindrance comes into play so reactivity decreases.